The aim of this study was to identify contraceptive behavior and determinants of Modern Contraceptive Methods (MCM) use among female students at the University of Lubumbashi (UNILU) in DR Congo. Methods: a cross-sectional analytic study, running from June 06, 2016 to March 21, 2017 among female students at two faculties of university of Lubumbashi (Faculty of Medicine and the Faculty of Letters and Humanities). An exhaustive sampling of 329 sexually active female students, secondary of 1341 female students present on the day of the survey. Socio-demographic variables, knowledge, attitudes and practices of MCM were analyzed, and logistic regression was performed. Results: The average age of all sexually active female students was 22.9±3 years, 9 out of 10 students had heard of contraceptive methods (CM), and teachers were the main source of information, followed by friends and family. Condoms were the method most frequently cited and used by respondents. Determinants of MCM use among female students were: «hearing about MCM from friends/family», «knowledge of condoms», «having used an MCM at first intercourse», «having been pregnant in her life», «sharing information about MCM with sexual partner», and «knowing that MCM were available in pharmacies». Conclusion: To increase the use of MCM among female students, it is necessary to take into account the various predictive factors.