In this work, we propose to study the influence of soil and concrete mechanical properties on soil-structure interaction parameters. Soil-structure interaction is modeled by two parameters, the vertical (k) and horizontal (T) reaction modulus. These two parameters depend on the system’s geometric and mechanical characteristics. This study shows that the vertical reaction modulus is not an intrinsic characteristic but depends on soil and concrete parameters (Es νs, Eb and νb) and foundation dimensions. The analysis shows that soil parameters are more influential than foundation parameters.