Oil palm (Elaeis guineensis Jacq.) is an important crop in tropical agriculture, particularly in Côte d’Ivoire, where it is a major source of income and large-scale by-products. However, oil palm cultivation is confronted with several problems, including attacks by pests, particularly the beetles Prosoestus minor and Prosoestus sculptilis, which damage female inflorescences and production. These insects cause significant yield losses, compromising palm oil production. In this context of sustainable oil palm cultivation, efficacy of the biopesticide Astoun 50 EC on these pests was evaluated at Centre National de Recherche Agronomique of La Mé, Côte d’Ivoire. The study aimed to determine the effect of this biopesticide on populations of P. minor and P. sculptilis, and to assess its impact on the main pollinator, Elaeidobius camerunicus. Results showed that the toxic effect of Astoun 50 EC increased significantly with increasing doses, from 3.96.10-4 g/mL to 1.96.10-3 g/mL. The highest mortality rate was recorded in Prosoestus minor at 1.96.10-3 g/mL after 72 h observation (82.25 ± 4.57%). However, Astoun 50 EC also showed a negative effect on the pollinator E. kamerunicus, with 58.25 ± 4.71% mortality. This impact on the pollinator must be incorporated into the control strategy for these pests.