The uncontrolled use of synthetic fertilizers pollutes the environment. These products cause soil imbalance, leading to their leaching and infiltration by water into groundwater or waterways. It is therefore important to turn to sustainable, environmentally friendly agriculture based on biological improvement techniques using organic waste to mitigate the effects of synthetic inputs. This study aims to compare the effect of organic and/or mineral amendments on corn cultivation. To this end, the experimental design consists of a randomized Fisher block with three (3) replicates in which four (4) treatments were applied with compositions based on Tithonia diversifolia leaves, poultry manure, and NPK. The effects of the treatments were assessed using growth and production parameters. The organo-mineral amendment (poultry manure + Tithonia diversifolia + NPK) indicates that each of the fertilizers significantly induced vegetative growth. The yield of the treatments was 9.50 t/ha for the control, 13.47 t/ha for Tithonia diversifolia + chicken manure, 16.88 t/ha for NPK, and 21.55 t/ha for Tithonia diversifolia+chicken manure+NPK. The results show greater growth and yield in corn grown on plots amended with Tithonia diversifolia+chicken manure+NPK. This combination of fertilizers proved beneficial for soil amendment by mobilizing nutrients for the plant.