In Africa, and particularly in Benin, medicinal plants are the most widely used means of solving human and animal health problems. The Beninese flora is rich in plants used to treat gastrointestinal diseases of farm animals whose chemical and biological potentials are still unknown. It is to correct this insufficiency that the present work aims at the chemical and biological recovery of Khaya senegalensis. After phytochemical screening, the phenolic compound contents of Khaya senegalensis extracts were determined spectrophotometer. Antibacterial and antiradical activities were evaluated by microplate dilution methods and DPPH respectively. The active ingredients of K. senegalensis were characterized by GC/MS. Several metabolites have been identified. The crude extracts (ethanolic, hydroethanolic and aqueous extracts) of K. senegalensis showed a lower antiradical activity compared to ethyl ether (IC50=0.09 μg/ml) and ethyl acetate (IC50=1μg/ml) fractions, which are more active that BHA (IC50= 4.8μg/ml), quercetin (IC50=3μg/ml) which are synthetic compounds. From the antibacterial activity, it appears that the objective extracts and fractions of this plant have a bactericidal activity with respect to Escherichia coli and Klebsiella pneumoniae. From the results of the chromatographic analysis, it appears that the bark of K. senegalensis contains glycerol, glycerol ethanoate, pyrocatechol, octadecanamide and neoergosterone as major components. The diversity of metabolites, the anti-fungal and antibacterial activities of K. senegalensis, could justify the use of this plant in the veterinary pharmacopoeia in Benin.

Herbal medicines are the most widely used especially in rural areas to solve problems of human and animal health Saharan average. This paper reports the results of the chemical and biological studies of the root bark of Cochlospermum planchoni used by farmers in Benin in the treatment of gastrointestinal diseases of animals. Results obtained, it appears that the root bark of C. planchoni is rich in secondary metabolites such as flavonoids, polyphenols, tannins, anthocyanins, leucoanthocyanins, mucilages, saponins, sterols and terpenes. Regarding the extraction yield, the binary water-ethanol (50/50) allowed to have a better (23.2%) extraction yield this of plant. As for the quantification of the polyphenols content, it is practically insensitive to the nature of the extraction solvent on crude extracts of the root bark of C. planchoni. According to the tests of antiradical activity, both fractions ethyl ether and ethyl acetate (IC50 = 1?g/ml) showed a more interesting radical scavenging activity than that of quercetin (IC50 = 3?g/ml) and BHA (IC50 = 4, 8?g/ml) which are antiradical syntheses. The results from the test of antibacterial activity show that the fractions of ethyl acetate, diethyl ether and butanol are more active than of the crude extracts of C. planchoni on the four bacterial strains used in this study.