The extension of orthogonal frequency division multiplexing (OFDM) with Multiple input multiple output (MIMO) in Wireless communication is nostrum to fading. This brilliant combination has potential to expedient high data rate requirements and high performance over various impugning channels i.e. Time selective and Frequency selective. This paper presents the Nakagami Multiple input multiple output (MIMO) fading channel simulation and the comparison of BER performance of the frequency domain equalizers i.e. Decision feedback and maximum likelihood detection (ML). The result is provided for two transmitter and two receiver, 16 QAM modulation. The simulation result shows that the high diversity gain stability can be acquired by using the domain equalizers for SFBC-OFDM in Nakagami frequency selective fading channel. The implementation of domain equalizers for SFBC-OFDM system for the arbitrary values of m minimizes the intersymbol interference (ISI). Ml is the best coding for minimizing the error probability.