In sub-Saharan Africa, the relationship between modes of weed management by chemical molecules and soil quality, resulting remains little known or poorly farmers. This study highlights the influence of mineral fertilizer and herbicide on increasing grain yield of common bean in Lubumbashi by the maintenance of the weed population to a tolerable level. The experiment was installed on a device in a ferralsol split splot with 3 repetitions. The main plots consisted of three types of fertilizer: NPK1 (10-20-10); NPK2 (17-17-17) and NPK3 (14-18-18) at the rate of 200kg / ha and secondary plots of 3 doses of the herbicide glyphosate D1 (1.5l / ha); D2 (3 l / ha) and D3 (4.5 l / ha). Observations were made on growth parameters, yield and weed infestation rate on the plots. The results obtained showed that the highest yield was observed on plots with an average of NPK1avec 2,1t / ha, no dose of herbicide has influenced performance. However, the herbicide was ineffective with weeds; high levels of infestation plots by weeds were observed in plots receiving NPK3 and NPK2. The combination of mineral fertilizer and herbicide was ineffective and would be a solution to weeding a ferralsol if we added organic matter and providing a second application based on a selective molecule to complement the action of first applied near weeds.