The aim of this study was to determine the epidemiological profile and evaluate risk factors of acute pesticide poisoning. A retrospective study of poisoning cases, declared between January 2000 and December 2008 in different sanitary structure in Tadla-Azilal, then brought together in the Moroccan Poison Control Center, was conducted. This region is characterized by an important agricultural activity and knows a frequency of poisoning raised by this toxin. During the study period, 1027 acute pesticides poisoning cases were collected. Most resulted from the province of Beni-Mellal. The average age was of patients 27.15