Liver dysfunction is a major health problem .Excessive drug therapy, free radicals, environmental pollutants, and alcoholic intoxicants are the main causes of liver disorders. The present investigation was designed to evaluate its in vivo hepatoprotective properties of Canscorra decussata (family Gentianaceae) whole plant methanolic extract against paracetamol toxicity in rabbits. Hepatoprotective activities of methanolic extracts of C. decussata were examined against paracetamole induced liver damage in rabbits using silymarin as control. Enzyme activities of Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), and Alkaline Phosphatase (ALP), bilirubin total and direct billiribin were analyzed. Oral administration of methanolic extract exhibited significant hepatoprotective activity.
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