Oral candidiasis is a common opportunistic infection in diabetic patients. Candida albicans is colonized on different oral surfaces such as tongue, palate, dental caries and plaques. Different factors like age, sex, denture wears and smoking play role in amount and severity of colonization of this microorganism. Our goal was to determine the relationship between the existences of Candida Albicans in oral diabetic patient. This cross - sectional study was performed on 120 diabetic patients. After completing the questionnaire and collect saliva samples and smears from the mouth were cultured directly on sabouraud agar medium containing 0.005% chloramphenicol and for identified use of specific tests. Data were statistically analyzed using Chi-Square, Mann-Whitney, t-test and correlation tests. Overall, in this study from 120 patients, 61 cases (50.8%) had a positive culture for Candida. In this study, Based on observations Candida infection rates were relatively higher in older patients and in women. Infections among participants who used dentures (0.001P <) and have smoking (P <0.038) had significant relationship. The infection in people with type II diabetes is more than subjects with Type I diabetes. C. Albicans was the most common isolated Candida species in both groups. This study showed a high prevalence of Candidiasis and Candida colonization in oral samples of diabetic patients. Our goal was to determine the relationship between the existences of Candida Albicans in oral diabetic patient.