The aim of this study was in one hand to characterize fish population and to estimate catch per unit effort (cpue) and production in Potou lagoon. The present survey has been led in the Potou lagoon from April 2004 to March 2006. The data have been collected 10 days per month with an experimental fishing using a beach seine associated to commercial fishings data collected during the sampling days. Fish community inventoried on the Potou lagoon was composed of 38 species including left in 33 genuses, 23 families and 8 orders. A species (Parachanna obscura) was reported for the first time in the Ebrié lagoon. Fish fauna in the Potou lagoon was dominated by 4 orders (Perciformes, Siluriformes, Elopiformes, Clupeiformes) forming 97% and 99% of the total number and biomass respectively, with the Perciformes as main order (55% of fish total abundance and 49% of total biomass. Community was dominated by six species (82% of total abundance: Tilapia guineensis (18%), Elops lacerta et Ethmalosa fimbriata (17% chacune), Sarotherodon melanotheron (16%), Chrysichthys nigrodigitatus (9%) et de Polydactylus quadrifilis (5%). In Potou lagoon, catch per unit effort (cpue) showed variation according to fishing gear and seasons. Annual mean cpue varied from 39 kg/output (trap fishery) to 1008 kg/output (beach seine fishery), with maximum values during the dry season (16 to 580 kg/ output) et minimum in the rainy season (11 à 134 kg/ output). Annual production in Potou lagoon was estimated to 526.584 tons, with a yield of 250 kg/ha/year.