The present study was aimed at determining the epidemiological profile and risk factors of poisonings in the north central region of Morocco (Meknes-Tafilalet) in 2013-2014. The data collected from a survey that was carried out on the poisonings registered by health delegations and hospitals in the region in 2013 and 2014, in addition to poisonings reported to the poison control and pharmacovigilance center of Morocco (PPCM) during the same period were subjected to a descriptive epidemiological analysis. The survey detected 2530 intoxications of different types outside of the scorpion stings. Following transmission to the PPCM and elimination of 1185 duplicates, our survey was able to list 1345 new cases, to have 4142 cases in 2013 -2014. According to the data analyzed: 58.6% of the intoxicated was adults, the Sex ratio (male / female) = 0.68, 83.37% of cases were recorded in urban areas. 54.49% progressed favorably, while 23 patients died. Poisoning was symptomatic in 40.24% of cases. The highest incidence was recorded in Ifrane city (2.15 ‰), but Meknes city registered the highest fatality rate (1.2%). these poisonings were caused by gaseous products in 41.6% of cases. The number of new poisonings collected during our survey was important: 1345 cases not reported to the PPCM, which means that Health officials should intervene in time to the statements of poisoning, in order to participate in the fight against their harmful effect on the health.