The study on evaluation of grain corn productivity of CMS 8501 variety was conducted in 04 sites of the North region, notably (Ngong, Touboro, Pitoa, and Béré). The objective of this study was to evaluate the grain corn productivity parameters in order to determine the technical way of production that provides the optimal result of grain corn production. The Fischer block combining 04 treatments with 06 repetitions was used to conduct this experimental field in the different test sites. The Linear Programming (LP) method and the Variance Analysis (ANOVA) were used to analyze obtained results. At 5% degree of significance, data analysis revealed that, the influence of the fertilizer formulation grain corn productivity is function of each locality (soil type) of production. On the other hand, the fertilizer formulation factor alone does not have a great influence on grain corn productivity. The cost-benefit analysis shows that, profit is maximized using the fertilizer formulation B = 12-20-18-5S-1B2O3 because it permits to get the best physical and economic maximum production in the zone of Béré compared to other areas. To validate this result the Linear Programming (LP) gave an optimal profit result of 168 095.65 CFA francs by using formulation B in the zone of Béré, a difference of 7 124.85 CFA francs representing lost gain produce of the corn grain productions in other localities. Our model (LP) recommends to the producers of the Béré localities, the production of corn on an area of 0.25 ha, to be able to optimize a profit of 168 095 CFA francs by combining respectively 3 360 CFA francs for the capital rent of the ground; 29 120 CFA francs for the fertilizers; 2 464 CFA francs for the capital packaging of seeds and herbicides; and above all, a higher intensity (168 man/day) of labor is necessary.