The Covid-19 outbreak is a global pandemic officially declared on March 12, 2020, with more than two million deaths. To assess the role of Procalcitonin as a biomarker of the specific inflammatory response and C-Réactive Protein as a stable and early biomarker of acute inflammation in pathogenesis and disease severity, we conducted a prospective descriptive study in the biochemistry laboratory of the Ibn Rochd University Of Casablanca Morocco in Covid-19 positive patients hospitalized in resuscitation. These biomarkers were abnormally increased in most of these patients. All of the patients who died had a positive admission CRP that would support a positive correlation between the increase in CRP and the severity of infection, without any correlation between CRP values in our study population with age or sex. The follow-up of the PRC could reflect its severity and should be used as a key monitoring indicator for Covid-19. PCT values at admission can predict the progression to a severe form of the disease. However, its synthesis is inhibited by interferon (INF) -γ, whose concentration increases during Coronavirus-2 infection.
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