Through its involvement in a quality approach, the medical biology laboratory (MBL) seeks above all to satisfy the needs of its customers. The question is whether the production processes and improvements undertaken by the biologist are converging towards optimum performance. In order to do this, an effective evaluation process must be set up to assess the extent to which the MBL is meeting the requirements and objectives it has set itself. The aim of this paper is to identify the performance indicators of an MBL’S operational process and to develop a dashboard for evaluating its performance. For this study, we surveyed the literature to identify the various indicators used to measure business process performance. Once the indicators had been selected, we proceeded to contextualize and validate them by organizing a focus group. This focus group enabled us to add certain indicators and eliminate others, and to design a dashboard that offers a global and synthetic vision, and represents a turnkey solution for biologists to monitor laboratory activity in a quest for effectiveness and efficiency.

Bisalbuminemia is a rare electrophoretic abnormality of the albumin fraction, characterized by a doubling of this fraction on the electrophoretic trace of serum proteins, reflecting the presence in the same individual of normal plasma albumin and structurally altered albumin, which may be of acquired etiology, rarely hereditary. The aim of this article is to study the etiologies and prevalence of bisalbuminemias associated with nephropathies discovered on serum protein electrophoresis at the biochemistry laboratory of the university hospital Ibn Rochd in Casablanca. This is a retrospective study of serum protein electrophoretic capillary tracings revealing bisalbuminemia in patients hospitalized in the nephrology department at university hospital Ibn Rochd in Casablanca over an 18-month period. 29 electrophoretic profiles out of 242 showed bisalbuminemia, i.e. 12% of all electrophoretic tracings in 29 patients presenting with acute or chronic nephropathy. The average age was 45±22 years, with a sex ratio (M/F) of 2.22. The etiologies of the nephropathies were dominated by renal amyloidosis with 24.14%, followed by minimal glomerular lesion nephropathies, extramembranous glomerulonephritis and lupus nephropathies with 17.24% each, and finally membranoproliferative glomerulonephritis with 6.9%. Among secondary etiologies, betalactam use was highlighted in 13.8% of cases, no patient in the series had a labelled pancreatopathy, and the presence of a monoclonal gammapathy was objectified in only one case in the series. This study illustrates the varied etiologies of bisalbuminemia associated with nephropathy, requiring detailed knowledge to enable proper interpretation of electrophoretic profiles.

Background: Hypothyroidism is among the most common endocrine disease; it is often associated with dyslipidemia which increases cardiovascular risk. This study was conducted to study the prevalence and profile of dyslipidemia during primary hypothyroidism and justify screening for dyslipidemia during hypothyroidism.Methods: Retrospective study, in the biochemistry department CHU Ibn Rochd of Casablanca from 2019 to March 2020 involving all patients who received a lipid assessment and a TSH (Thyroid Stimulating Hormone) assay in the biochemistry laboratory. TSH was estimated by an immunoenzymatic method: chemiluminescence. The LDL-assayed (Low Density Lipoprotein), HDL (High Density Lipoprotein), TG (Triglycerides), CT (Total Cholesterol) parameters were estimated by an enzymatic colorimetric method, the LDL-calculated was calculated by the friedwald formula.Results: These were 1046 patients: 66.73% Women, 33.23% Men (sex ratio M / F = 0.49). The mean age was 41.66 years ± 13.86. The mean TSH value was 23.09 mIU / L. Dyslipidemia was noted in 91.78% of cases.The prevalences of, hypoHDLemia, hypercholesterolemia, hypertriglyceridemia, hyperLDLemia, were respectively: 82.12%; 32.5%; 23.32%; 10.8%.The correlation between TSH and LDL was negative (P> 0.05) while it was positive with TG (P> 0.05), HDL (P <0.05) and CT (P> 0.05).Conclusion: Hypothyroid patients show a significant increase in serum lipids. This atherogenic lipid profile should be systematically sought when monitoring patients with hypothyroidism to prevent cardiovascular complications.

The delocalized medical biology examinations are carried out outside the laboratory near the patient by staff outside the laboratory, which saves time in obtaining the results. These examinations are subject to the same regulations as examinations carried out in a medical biology laboratory and are the responsibility of medical biologists who retain responsibility for validating the results obtained.This development of the implantation of analytical devices of medical biology in the care units (outside the laboratory of the hospital) can be justified by several factors: medical emergencies, organizational constraints, the distance from the laboratory....In this work we tried to analyze the state of affairs of delocalized biology and to reveal the problems of delocalized biology of our ibn Rochd hospital center in Casablanca.

The Covid-19 outbreak is a global pandemic officially declared on March 12, 2020, with more than two million deaths. To assess the role of Procalcitonin as a biomarker of the specific inflammatory response and C-Réactive Protein as a stable and early biomarker of acute inflammation in pathogenesis and disease severity, we conducted a prospective descriptive study in the biochemistry laboratory of the Ibn Rochd University Of Casablanca Morocco in Covid-19 positive patients hospitalized in resuscitation. These biomarkers were abnormally increased in most of these patients. All of the patients who died had a positive admission CRP that would support a positive correlation between the increase in CRP and the severity of infection, without any correlation between CRP values in our study population with age or sex. The follow-up of the PRC could reflect its severity and should be used as a key monitoring indicator for Covid-19. PCT values at admission can predict the progression to a severe form of the disease. However, its synthesis is inhibited by interferon (INF) -γ, whose concentration increases during Coronavirus-2 infection.

Bis albuminemia is a rare qualitative anomaly, it is hereditary or acquired and transient and physiopathology remains a little unknown. Indeed, the study presents 6 cases of bis albuminemias collected on 2083 serum protein electrophoresis carried out at the laboratory of biochemistry of CHU Ibn Rochd of Casablanca over a spread period of one year (2018). The results of electrophoresis serum proteins of 6 reported cases showed bis albuminemias which are all of acquired and transient type, of which 3 cases are related to the drug intake of betalactamine antibiotic and the other 3 are related to the syndrome nephrotic.

Introduction and purpose : The prescription of the serum protein profile is useful in the diagnostic orientation of certain immune, inflammatory and nutritional diseases. It is recommended by the senior health authority who defines the conditions. We study the conditions of this prescription by evaluating its relevance in the hospital services of Ibn Rochd University Hospital in Casablanca. Method : a descriptive and cross-sectional study conducted by a questionnaire containing 23 questions, 4 closed questions, 14 multiple-choice questions, 4 closed-ended questions and an open-ended question form 48 doctors. Results of the study : 81.8% of doctors have not been trained in serum protein profile and 72.9% have gaps in their knowledge of the protein profile. 55.7% of doctors say that biological advice is a great contribution. Conclusion : A relevant prescription requires a good enough training and complementarity between clinicians and biologist because of an accelerated diagnosis.

Introduction: As a consequence of the discovery of numerous abnormalities in the prescription of biochemistry emergency parameters, the objective of this work was to establish an inventory of the emergency prescriptive practices within hospital departments of Ibn Rochd university hospital of Casablanca, for possible corrective actions. Material and methods: A prospective transversal descriptive study was carried out on all the biochemical assessments prescribed during the guards (nights and weekends) and done in the laboratory of biochemistry of UH-Ibn Rochd of Casablanca, from June 1st to October 31st, 2015. The statistical analysis was done on Excel. Results: During the study period, we received 9020 biochemical assessments with 73216 parameters. About 12% of these assessments were prescribed by non-emergency departments (and 88% by emergency departments). We found that non-emergency parameters were prescribed with a relative high frequency such as lipid status (triglycerides accounted for 0.48% of prescriptions (n = 352), total cholesterol 0.45% (n = 330) and LDL-cholesterol and HDL-cholesterol 0.3% (n = 220). In addition to this, 90% of the prescriptions were sent without clinical information. Discussion and conclusion: This study revealed dysfunctions concerning the prescription of emergency biochemical assessments. For this purpose, a clinical-biological collaboration is necessary to implement corrective actions such as the drafting of prescription procedures of emergency assessments.

Introduction and purpose: The serum protein profile is a very important examination for the diagnosis, monitoring, surveillance and evaluation of certain inflammatory, immune and nutritional diseases, but its prescription remains a little limited. According to the recommendations of the good practices in biology, the prescription of this examination must be carried out under precise conditions. In our context, this technique is poorly prescribed by physicians. The objective of this work is to assess the state of the art of internal and residents doctors regarding the serum protein profile. Method: This is a descriptive, quantitative, exploratory and cross-sectional study supported by a 22 questions questionnaire, with closed questions in numbers of 4, 14 multiple-choice questions and 4 closed-ended questions from 59 physicians. This questionnaire evaluates their knowledge and their need for serum protein profile training as well as their expectation of benefits at the biochemistry laboratory. Results of the study: The exploitation of the results showed a lack of formation in protein profile. 96.3% of resident and internal pediatric physicians did not receive training in this area. 37.5% have unsatisfactory theoretical knowledge of the targeted protein profile. 40.7% of responders indicated that satisfaction with the biochemistry laboratory's performance is moderately satisfied concerning the response time. Conclusion: Training in protein profile is considered necessary for the prescribing doctors in order to consolidate their knowledge for a more useful prescription for the purpose of an improved diagnosis.