Several nations have integrated food security for a long time, thus undertaking a fight against malnutrition in all its forms. This work aimed to inventory the indigenous leafy vegetables of the prefecture of Lobaye in the Central African Republic. To do this, an ethnobotanical survey was conducted among 144 people. The survey was carried out during the period from May to October 2022. In total, sixty-three (63) species were identified, grouped into forty-six (46) genera and belonging to thirty-one (31) botanical families. The sub-prefecture of Pissa totals 56 species, that of Boda 54 and 48 for that of M’baïki. The most represented families are Tiliaceae (6 species) and Moraceae (5 species). The analysis of ethnobotanical data revealed that the leaf is the most used organ (95.24%); 66.67% of leafy vegetables are consumed as complementary nutritional sources while 33.33% are functional foods. Cooking is the most used method of preparation (98.41%). The biological forms that produce more leaves consumed are herbs (38.09%). The habitat of these species is in particular the forest, fallow land and fields. The well-known species (50 to 100%) are fourteen (14) in number or 22.22% of the total specimens. In addition, the results showed that fourteen (14) LFI species are subject to significant trade in local markets. This study showed that there is still a high diversity of LFI species in the prefecture of Lobaye in the Central African Republic.