Rabies is a deadly disease that can spread between mammals. Morocco is a rabies-endemic country. To maintain rabies-free status, some countries require rabies antibody titration tests. This titration is subject to variation. This retrospective study was conducted to determine the factors associated with humoral response variation in rabies-vaccinated domestic cats in the context of pet movements. Factors such as the animal’s sex, its age, the laboratory, the test used (FAVN or RFFIT), the time between vaccination and rabies titration sampling, and the number of vaccinations were taken into account. Information on 959 cats was collected, and structural modeling utilizing logistic multinomial regression was used. The results showed that 57.1% of the cats had a titer exceeding 10 IU/ml, 32.1% had a moderate response (3