Laboratoire de Physiologie, Pharmacologie et Pharmacopée (L3P). Unité de Formation et de Recherche-Sciences de la Nature (UFR-SN), Université Nangui ABROGOUA (UNA), 02 BP 801 Abidjan 02, Côte d’Ivoire
Justicia flava is a plant commonly used because of its several pharmacological properties. In this work seventy (70) rats were divided into 7 groups of 10 animals consisting of five males and five females each in order to check the subacute toxicity and the effects on the kidney of this plant. To do this, the animals were administered daily, orally and for 28 days with doses of 125, 250, 500 and 1000 mg/kg bw of the aqueous extract of J. flava. The results showed that this extract was non-toxic on renal function. At these doses, the extract did not cause any significant variation in serum levels of electrolytes (chlorine, sodium, calcium, and potassium). Likewise, renal markers like urea and creatinine showed no significant variation. No structural abnormality in the kidney tissues of treated rats compared to control rats was revealed during this experiment. In conclusion, the aqueous extract of J. flava is safe and without toxic effects for the kidney.
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