Justicia flava is a plant commonly used because of its several pharmacological properties. In this work seventy (70) rats were divided into 7 groups of 10 animals consisting of five males and five females each in order to check the subacute toxicity and the effects on the kidney of this plant. To do this, the animals were administered daily, orally and for 28 days with doses of 125, 250, 500 and 1000 mg/kg bw of the aqueous extract of J. flava. The results showed that this extract was non-toxic on renal function. At these doses, the extract did not cause any significant variation in serum levels of electrolytes (chlorine, sodium, calcium, and potassium). Likewise, renal markers like urea and creatinine showed no significant variation. No structural abnormality in the kidney tissues of treated rats compared to control rats was revealed during this experiment. In conclusion, the aqueous extract of J. flava is safe and without toxic effects for the kidney.

The objective of this study was to perform triphytochemistry and to evaluate the effect of aqueous (AqE) and hydroethanol (EthE) extracts of Spathodeae campanulata on blood glucose and pancreatitis markers in streptozotocin (STZ) -induced diabetic male rats. S. campanulata P. beauv, is a plant belonging to the Bignoniaceae family which is traditionally used for the treatment of diabetes, malaria and schistosomiasis. In a first step, we performed triphytochemistry of the extracts which showed that the aqueous and hydroethanolic extracts of the barks are rich in polyphenols, flavonoids, saponosides, alkaloids, sterol-polyterpenes, tannins but relatively poor in quinones. In a second phase, this study consisted in evaluating the effects on glycaemia and markers of pancreatitis of AqE and EthE of S. campanulata administered to 46 male rats of the Wistar strain divided into 9 batches of four male rats made diabetic each by intraperitoneal injection of a single dose of 60 mg/kg/bw of STZ. After 28 days of treatment with 200, 400 and 800 mg/kg/bw of S. campanulata AqE and EthE, blood glucose, alpha amylase and lipase activities were significantly decreased with both extracts.