Traditional henna rarely causes adverse events. However, to obtain a black color, many ingredients are mixed with this plant such as paraphenylene diamine and solvents. The aim of our study is to describe severe cutaneous adverse events caused by black henna collected at the Moroccan Pharmacovigilance Centre. Materials and Methods: We analyzed the coetaneous adverse reactions associated with the use of black henna, collected during 2012 in Morocco. The severity ofreactions wasan inclusion criteria. We analyzed the characteristics of patients, adverse reactions and type of exposure. Results: Nine serious cutaneous cases were collected, which represent 6.42% of all adverse reactions related to cosmetics products. Hospitalization and sequelae were the reason of seriousness. Outcomes were favorable for all cases. Conclusion: the severity of those cases showed the importance of the pharmacovigilance of cosmetics products.
Cutaneous adverse reactions induced by drugs are common. They occur in 1 to 3% of drugs users. The aim of this study is to determine the frequency of cutaneous adverse drug reactions, describe the clinical aspects of these reactions and determine the scores of imputability relating the possible drug-effect relationship in Morocco. This is a prospective study of cutaneous adverse drug reactions occurring in patients in El Idrissi hospital in Kenitra during the period April 2012-April 2013. The analysis of cause-effect relationships between the drug and the occurrence of clinical and paraclinical effects is conducted by the French causality assessment method with 7 scores from 0 to 6. Among 5137 hospital admissions, 45 patients developed 53 cutaneous adverse drug reactions, which was 1.02%. The average age of the patients was 35.39
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