Juvenile granulosa tumor is a sex cord stromal tumor extremely rare, with usually estrogenic effects, while virilizing form is exceptional, often discovered at a stage confined to the ovary, justifying therefore a conservative treatment. Its prognosis appears favorable, depending on early management. However, its evolvement may be hampered by early and aggressive recurrence. We report a new case compiled in Obstetrics Gynecology Service (HMIMV) of virilizing form of juvenile granulosa cell tumors, discovered during a recent exacerbation of a preexisting androgen syndrome in a girl of 24 years. It's extreme rarity prompted us to report it highlighting, through a literature review, its diagnostic features, therapeutic and evolutionary.
The neurofibromatosis type 1 (NF1) or von Recklinghausen's disease is an autosomal dominant disease. The association of NF1 to breast cancer is unusual and rarely r eported in literature. We report a case of this rare association. The discovery of breast cancer at a 51 years old patient in an advanced stage (T3N1M0), occasioned the appearance of dermatological lesions which are pathognomonic of neurofibromatosis1. Monitoring of patients with neurofibromatosis type1 seems justified to detect Early a possible association to breast cancer.
Bowen vulvar disease is defined as squamous cell carcinoma strictly intraepithelial, it's a viral infection which mostly affects postmenopausal women. It can be associated to other lesions specially gynecological cancers. The diagnosis is essentially histological. The evolution can go to invasion. Its treatment is based on surgery. We report the case of a female patient of 46 years, who consulted for a vulvar ulceration range of 5 cm in diameter, treated with wide excision, the histological examination is in favor of Bowen's disease. Through a review of litterature, we focus on the clinical, evolutionary and therapeutic features of this pathology.
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