Accidents at work are responsible for great suffering, great loss for employees and their families, employers and social security funds. Knowledge of these explanatory factors of occupational risks will enable the world of work to develop a coherent occupational safety and health program and to concretize the concept of decent work.The general objective is to study the determinants and consequences of occupational risks in the formal sector of Haut-Katanga.This is a multicenter historical cohort study including all the occupational risk files of workers in the formal sector in Haut-Katanga province.During the first phase (2010 to 2017), 510 work accident files were registered. The highest accident rate was recorded in 2012. Males accounted for 93.10%. The bride and groom were the most injured, 91.72%. The 1 to 10 year seniority bracket was the most rugged with 63.12%. The primary sector was the most rugged sector with 70.8% of which the miners represented 51.5%.Workers with a primary education level were the most injured with 83%. Multivariate analysis shows that workers in the primary sector are the most injured as are those with less than 7 years of seniority.The study carried out in a mining company during the second phase showed that out of a total of 338 workers, 14 cases of work accidents were recorded in 2016. Among the injured, 84.6% had a seniority of at least 5 years and 83.1% were assigned in mining operations.In view of the above, socio-demographic variables and the sector of activity are among the determinants of occupational risks.