For many years, education systems are in a promotion of education pupils with autism spectrum disorder. A conciderable number of this category of pupils are found in primary schools of Yaounde town which is likely to change the perception of many teachers. The objectif of this study is to describes the perception of the disability of primary schools teachers regarding school follow-up of pupils with autism spectrum disorder. For data collection of this study, semi-structured interview were carried out with five teachers who have in their classroom pupils with autism spectrum disorder. To better organise the interview, the thematic analyses of data was used. From the results obtained, it appears that the perception of teachers disability is expressed through attention, listening, individual control, the use adapted teaching matérials, additional hours, patience and the desire to succeed wich shows that, teachers have a positive perception of disability in general and the autism spectrum disorder in particular. This perception of disability by teachers will be an element favoring school follow-up of students with autism spectrum disorder.