The progressive loss of kidney function is associated with an inflammatory state and functional defects of the innate and adaptive immune system. The combined effects of increased activation and immune dysfunction could explain the susceptibility of patients in End Stage Renal Disease (ESRD) to viral and bacterial infections, their weak responses to vaccination and increased risk of malignant tumors and cardiovascular disease.
It is important to underline that these immune complications mainly affect patients on dialysis. The mechanisms of these immunological disturbances observed in ESRD patients are still unclear.
Early identification of chronic kidney disease allows implementing interventions to slow the progression to ESRD. Therefore, measures aimed at attenuating immune abnormalities in ESRD should be a main research area as this could lead to increased survival and better quality of life in HD patients.
Patients on dialysis are in a state of immunodeficiency, resulting in a high incidence of infectious complications. These patients are a population at risk for developing infection or reactivation with cytomegalovirus (CMV). The objective of this study is to determine the prevalence of CMV antibodies (IgM and IgG) among hemodialysis patients treated in CHU Ibn Rochd in Casablanca.
Patients and Methods: This transversal study of 87 hemodialysis patients and 30 controls was to search CMV antibodies (IgM and IgG) and assess risk factors of infection.
The control population was consisting of blood donors in blood transfusion center in Casablanca.
Results: The mean age of patients was 44.1
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