For the sustainable use of groundwater, this study analyzes groundwater potential in Western Cameroon Highlands using artificial neural network model (ANN), GIS tools and remote sensing. Twelve factors believed to influence the groundwater occurrence were selected from literature and field investigations and used as input data. Satellite ALOS PALSAR, LANDSAT OLI, SRTM data processing techniques and GIS spatial analysis tools were used to prepare these maps. Pumping rates from 189 wells were considered as groundwater potential data and randomly divided into a training and a test sets. An ANN based on the relationship between groundwater productivity data and the above factors was implement on MATLAB. Each factor