This study aims at demonstrating how and why the Horn of Africa is at the heart of geostrategic and geopolitical stakes of the Middle Kingdom: China at this time of globalization. As it is a gate of entering and exiting towards marine and terrestrial spaces, the Horn of Africa has an access to the Indian Ocean, the Red Sea and the Arabic Sea via Bab-el-Mandeb channel and the Aden Gulf Bay through the littoral of Djibouti which is a commercial crossing point between Asia, Europe and Africa, hence justifying its geopolitical importance. The geopolitical and geostrategic stakes of China in the Horn of Africa would be motivated by three reasons. First, it gives access to the Pacific Asia via the Red Sea, the Arabic Sea and the Indian Ocean; second, the Horn of Africa gives access to Europe through the Mediterranean Sea via the Red Sea by passing through the Suez Channel; and third, it allows the access to these two continents via these crossing points towards Africa and vice versa. It also represents an opportunity for the expansion of this kingdom in the world. The defense and security of its vital interests out of its borders through its military base in Djibouti shows how this chessboard would be at the heart of geostrategic stakes of China. This would help to understand the ambitions of Beijing to rival the USA, Japan for preventing them from taking over vital spaces and enlarging their dominion in the Afro-asiatic mass. The hypotheses which stipulates that the exit and entrance peripheries or ways are the dominion key at the global level for every State that masters them would give sense to this analysis.