Objective: To determine the epidemiologic profile of tumours at the regional hospital of Ngaoundéré. Materials and methods: It was a descriptive retrospective design study carried out over a period of five years (2011-2015), on benign and malignant tumours diagnosed clinically and histologically with confirmed results from the laboratories of anatomic pathology of the university hospital of Yaoundé (CHU) and Centre Pasteur of Garoua. The studied parameters where age, sex, type of tumour, site of localisation, histopathological diagnoses, surgical resection. Results: A total of 215 cases of tumours was registered amongst which 86.97% was benign and 13.03% malignant with a predominance sex ratio of 3:1 in favour of females. Ages varied in women between 31- 40 years with a mean age of 36.8 years for benign cases and 48.8 years for cancers. Leiomyoma with 50% was the most frequent of all benign tumours followed by fibro adenomas of the breast. Concerning malignant tumours, breast cancer recorded the highest frequency followed by the cancer of the cervix. In males, 24% of benign and 54% of malignant tumours were recorded within the age range of 51- 60 years for benign and 61-70 years for malignant. Benign prostate hypertrophy was the main tumours affecting men with a percentage of 68.88%, whereas, the most prevalent male cancer was still that of the prostate gland followed by the colorectal cancer. Conclusion: Though the number of populations in this study was not representative of the Adamawa region, the incidence was similar to those observed in other countries as such, risk factors of tumours were the same therefore this study will better equip health leaders so as to develop and reinforces strategies put in place to better manage, mobilize resources and take preventive measures so as to reduce their incidence.