DNA sequence DNA Sequencing is the first step in establishing phylogenetic trees, protein structure prediction, diagnosis of cancer, discovery of drugs and hence its importance cannot be underestimated. DNA sequencing finds its use in the diagnosis of oral squamous cell carcinoma (OSCC). Oral Cancer is the most common occurring malignancies in the world, especially in India where the prevalence for smoking, Areca nut chewing coupled with a lifestyle that encourages these two activities as fashion are left many people diagnosed with OSCC. Patients with this OSCC are more likely unaware of its side effects and over time might suffer from facial deformity. The importance to understanding the symptoms, prevention and treatment of oral cancer is very much essential today. In this paper, we looked at over 2000 odd papers published and look at the correlation between the next Generation DNA sequencing algorithms (NGS) play an important role in diagnosis of OSCC. This is a further study on some of the papers which have highlighted NGS role in OSCC Diagnosis. We did like to see a comprehensive review on the papers published so far. In the discussion, we will see frequently mutated genes in the OSCC, recent discoveries and OSCC treatment based on the findings.

DNA sequence Cigarette Smoking, Betel leaf chewing, and alcohol consumption are major cause of oral cancer in Asia. The difficulty in quitting, coupled with patients’ economic conditions affects the inability to get diagnosed early, driving death rate higher. There has been major advancement in molecular sciences, computational biology, and other fields today, but we are not still able to pinpoint the causes of oral cancer, also known as Squamous Cell Carcinoma (OSCC). Early detection leads to better survival rate, therefore, education on yearly check-ups plays a vital role. Computational analysis at the genomic (DNA sequence) can help patients with targeted cellular treatment and hopefully a cure. In this paper, we would look at computation tools used in detecting OSCC and various analysis. Analysis includes detecting abnormality in the cell and other molecular reactions which later morph into a cancerous cell. Later, we investigate all computational tools or techniques from local and global sequence alignment, protein structure, gene, functional structure analysis which help medical staff detect cancer, which in turn can help with oral cancer treatment, prognosis and hopefully a cure.