The bacteria producing beta-lactamases extended spectrum are the leading cause of treatment failure observed in the treatment of bacterial infections. This study aims to evaluate the antibacterial effects of extracts hexanical, 70% methanol and aqueous leaf Spondias mombin (Desr.) A. Juss. (Anacadiaceae) on six clinical isolates of Enterobacteriaceae producing beta-lactamases with extended spectrum (ESBL) and a reference strain. The study of the antibacterial activity of the extracts was performed by the medium diffusion method and agar dilution Mueller-Hinton. For phytochemical screening extracts, chromatographic characterization method thin layer was used. It emerged from this study that the aqueous and hydro-alcoholic extracts are actives. They are bactericidal for the majority of tested strains with MICs ranging from 0.39 to 1.56 mg / mg for the 70% methanol extract and 0,39 to 3.125 mg / ml for the aqueous extract. The phytochemical screening revealed a wealth of secondary metabolites such as saponins, tannins, flavonoids, sesquiterpenes, polyphenols, coumarins may be beneficial in the treatment of many diseases in Enterobacteriaceae.

The present survey consisted in a first time, to make a biological assessment carrying on the potential antibacterial and analgesic activities of ethanolic decoctions from Schrankia leptocarpa, the whole plant (P) and its different organs: stem (T), roots (R), leaves (F), fruit, as well as stem-roots (TR), roots-leaves (RF), leaves-stem (FT) combinations. It revealed that all excerpts sign a bactericidal activity against 3 strains of Streptococcus mutans, with a MIC ranging from 6.25 mg/mL to 12.5 mg/mL. However, only the excerpt R exhibits a good analgesic activity. In the second time, a phytochemical screening of the excerpt R has been achieved on the basis of bio-guided tests, after which, the presence of various secondary metabolites (free quinones, saponosides, polyphenols, coumarins, flavonoids, gallic tannins, alkaloids) has been put in evidence.